Endocrine Abstracts

Chronic stress or excess glucocorticoids may promote brain ageing and cognitive decline. Elevated blood cortisol levels or increased sensitivity to cortisol’s action in brain cells play a crucial role in the development of age-dependent memory deficits. It is now recognized that the concentration of glucocorticoids within specific tissues including brain are derived not just from blood hormone levels but also from the local regeneration of active glucocorticoids by 11&#94...

Mice with congenital adrenal hyperplasia due to a null mutation of cyp11b1, the gene encoding the steroidogenic enzyme 11β-hydroxylase, have low glucocorticoid levels, reduced adiposity and increased liver weight. It is notable that null mice are also glucose intolerant. Here, we have investigated these phenotypes in more detail. Plasma corticosterone levels were less responsive to restraint stress and cholesterol and triglyceride levels were not significantly different i...

Neurosteroids are synthesized locally within the central nervous system and play essential roles in modulating neuronal activity and various brain functions. They can have a wide range of effects, including anxiolytic, sedative, analgesic, and neuroprotective actions. Understanding their distribution in the brain and how they interact with neurotransmitter systems is of significant interest to researchers studying brain function and related disorders. We aim to construct a 3D ...